Applied Physiology and Nutrition Research Group, School of Physical Education and Sport, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, BR
Low‐load resistance training with blood flow restriction increases muscle function, mass and functionality in women with rheumatoid arthritis
- Published on April 29,2019
Objective: To evaluate the effects of a low‐load resistance training program associated with partial blood flow restriction in patients with rheumatoid arthritis (RA).
Methods: Forty‐eight women with RA were randomized into one of the three groups: high‐load resistance training (HL‐RT: 70% one repetition maximum [1RM]); low‐load resistance training (30% 1RM) with partial blood flow restriction (BFRT) and control group. Patients completed a 12‐week supervised training program and were assessed for lower‐limb 1RM, quadriceps cross‐sectional area (CSA), physical function (timed‐stands test [TST], timed‐up‐and‐go test [TUG], Health Assessment Questionnaire [HAQ]) and quality of life (Short Form Health Survey [SF‐36]) at baseline and after the intervention.
Results: BFRT and HL‐RT were similarly effective in increasing maximal dynamic strength in both leg press (+22.8% and +24.2%, all p<0.0001) and knee extension (+19.7% and +23.8%; all p<0.0001). Quadriceps CSA was also significantly increased in both BFRT and HL‐RT (+9.5% and +10.8%; all p<0.0001, respectively). Comparable improvements in TST (+11.2% and +14.7%; all p<0.0001) and TUG (‐6.8%, p<0.0053 and ‐8.7%, p<0.0001) were also observed in BFRT and HL‐RT, respectively. Improvements in both groups were significantly greater than those of CG (all p<0.05). SF‐36 role physical, bodily pain and HAQ scores were improved only in BFRT (+45.7%, +22.5% and ‐55.9%, respectively; all p<0.05). HL‐RT resulted in one case of withdrawal and several cases of exercise‐induced pain, which did not occur in BFRT.
Conclusion: BFRT was effective in improving muscle strength, mass, function and health‐related quality of life in patients with RA, emerging as a viable therapeutic modality in RA management.
- Reynaldo Rodrigues 1
- Rodrigo B. Ferraz 1
- Ceci O. Kurimori 2
- Lissiane K. Guedes 3
- Fernanda R. Lima 3
- Ana L. de Sá‐Pinto 3
- Bruno Gualano 3,1
- Hamilton Roschel 3,1
Institute of Radiology, Universidade de São Paulo, Sao Paulo, SP, BR
Rheumatology Division; Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, BR, University of Sao Paulo, SP, BRAZIL
Arthritis Care & Research