Research Study Abstract

Can Replacing Sitting Time with Standing Time Improve Adolescents’ Cardiometabolic Health?

  • Published on Aug 27, 2019

Abstract: This study aimed to assess the effects of isotemporal replacement of sitting time (SIT) with standing (STA) on cardiometabolic biomarkers. In this cross-sectional study, male adolescents wore the GT3X+ activity monitor for 7 days to measure the SIT and STA. Moderate-to-vigorous physical activity (MVPA) was estimated by a youth-specific cut-off point. An isotemporal substitution approach was used to examine the e ffects of replacing di fferent periods of SIT (15, 30, 60, and 120 min) with STA on cardiometabolic biomarkers [total cholesterol (TC), high-density lipoprotein cholesterol (HDL-c), non-HDL-c, low-density lipoprotein cholesterol (LDL-c), triglycerides (TG), glucose, insulin, HOMA2- , HOMA2-S, and HOMA2-IR]. Analysis of covariance (ANCOVA) with a post-hoc Bonferroni test was used to compare the adjusted means between the four subgroups that were clustered according to SIT and STA amount. Adolescents (n = 84; age, 16.7  0.9 years) wore GT3X+ for 15.2  2.3 h, for 6.7  0.6 days. Isotemporal substitution of SIT with STA was associated with TC, non-HDL-c, LDL-c, and TG. ANCOVA results showed a statistically significant diff erence for TC, non-HDL-c, and LDL-c. These findings showed that for male adolescents, sitting less and standing more may be an e lective alternative to reduce cardiometabolic biomarker levels related to lipid metabolism, regardless of MVPA.


  • Bruno P. Moura 1
  • Rogério L. Rufino 1
  • Ricardo C. Faria 2
  • Jeffer E. Sasaki 3
  • Paulo Roberto S. Amorim 2


  • 1

    Medical Science Graduate Program, Medical Sciences Faculty, Rio de Janeiro State University, Rio de Janeiro 20550-170, Brazil

  • 2

    Department of Physical Education, Viçosa Federal University, Viçosa 36570-900, Minas Gerais, Brazil

  • 3

    Graduate Program in Physical Education, Federal University of Triângulo Mineiro, Uberaba 38025-180, Minas Gerais, Brazil


International Journal of Environmental Research and Public Health

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Can Replacing Sitting Time with Standing Time Improve Adolescents’ Cardiometabolic Health?


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