Featured Research

  • Physical Activity in Pediatric Pulmonary Arterial Hypertension Measured by Accelerometry: A Candidate Clinical Endpoint

    Background Although the six-minute walk distance is well established as a clinically relevant endpoint for adults with pulmonary arterial hypertension (PAH), this endpoint is less applicable to infants and children who may be unable to participate in such testing. Thus, there is a critical need to develop and validate means of assessing activity levels in younger populations that can be applied to clinical trial design. Accelerometry has previously been used ...


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  • Accelerometer Data Collection and Processing Criteria to Assess Physical Activity and Other Outcomes: A Systematic Review and Practical Considerations

    Background: Accelerometers are widely used to measure sedentary time, physical activity, physical activity energy expenditure (PAEE), and sleep-related behaviors, with the ActiGraph being the most frequently used brand by researchers. However, data collection and processing criteria have evolved in a myriad of ways out of the need to answer unique research questions; as a result there is no consensus. Objectives: The purpose of this review was to: (1) compile and classify ...


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  • Measuring free-living physical activity in COPD patients: Deriving methodology standards for clinical trials through a review of research studies

    Abstract: This article presents a review of the research literature to identify the methodology used and outcome measures derived in the use of accelerometers to measure free-living activity in patients with COPD. Using this and existing empirical validity evidence we further identify standards for use, and recommended clinical outcome measures from continuous accelerometer data to describe pertinent measures of sedentary behaviour and physical activity in this and similar patient populations. ...


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